Google Patents US4567045A - Isotonic glycerol free intravenous fat emulsion Therefore, This injectionTM should be administered with caution during pregnancy and lactation.US4567045A - Isotonic glycerol free intravenous fat emulsion Use in Pregnancy & Lactation: Absolute safety of the foetus and the nursing infant has not been established. In neonates receiving long term parenteral nutrition, particularly premature neonates, platelet count, liver function tests and serum triglyceride concentration should be monitored. In infants, metabolism of lipids in peripheral tissues may be diminished by infection and heparin administration. In low birthweight infants, the risk of lipid infusions may outweigh potential benefits due to further diminution of defences against infection. This injection should be given with caution to neonates and premature infants with hyperbilirubinaemia and in cases with suspected pulmonary hypertension. This injection should be administered with caution as a strong correlation exists between C-reactive protein and the agglutination of This injection in seriously ill patients. Fat metabolism may be disturbed in conditions such as renal insufficiency, uncompensated diabetes, pancreatitis, certain forms of liver insufficiency, metabolic disorders and sepsis. Cross allergic reaction has been observed between soya-bean and peanut. This injection contains soya oil and egg lecithin which may rarely cause allergic reactions. Do not use any bag in which there appears to be separation of the emulsion. Do not store partially used bags for later use. Fatty acid deficiency: To correct EFAD, supply 8% to 10% of the caloric intake by IV fat emulsion to provide an adequate amount of linoleic acid. The maximum recommended dosage is 3 g/kg/24 hours. Infants: Starts at 0.5 g/kg/24 hours and may be increased in relation to the infant's ability to eliminate fat. If no adverse reactions occur, the infusion rate can be increased to 1 g/kg in 4 hours. Children: Initial infusion rate is 0.1 ml/min for the first 10 to 15 mins. Do not exceed a daily dosage of 2.5 g/kg. Infuse only 500 ml the first day and increase dose the following day. If no adverse reactions occur, the infusion rate can be increased to 2 ml/min. Adult: Initial infusion rate is 1 ml/min for the first 15 to 30 mins. Fat emulsion should comprise no more than 60% of the patient's total caloric intake, with carbohydrates and amino acids comprising the remaining 40% or more of caloric intake. Total Parenteral nutrition: As a part of TPN, administer IV via a peripheral vein or by central venous catheter. Impaired renal function where a concentrated source of energy may be indicated to reduce protein breakdown Ĭachexia and Patients with essential fatty acid deficiency who cannot maintain or restore a normal essential fatty acid pattern by oral intake. following cranial trauma or poisoning in cases where enteral feeding is inappropriate or impossible Nutritional disorders or disturbances of nitrogen balance due to inadequate or failing intestinal absorption caused by tumours in the gastrointestinal tract, acute or chronic intestinal diseases (peritonitis, ulcerative colitis, terminal ileitis) īurns, to reduce the frequently excessive nitrogen losses Prolonged unconsciousness, eg. Preoperative and postoperative nutritional disturbances where an improved nitrogen balance is required Part of the intravenous diet in all parenteral nutrition indications including: It is a source of essential fatty acids when a deficiency occurs. This is a source of calories and essential fatty acids for patients requiring parenteral nutrition for extended periods of time (usually for >5 days).
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